Tadalafil + Sildenafil Combination
100% Online — No Office Visit Required
A compounded preparation pairing a long-acting and a short-acting PDE5 inhibitor in a single tablet — designed to combine the extended duration of tadalafil with the rapid onset of sildenafil in one as-needed dose.
Tadalafil 20 MG / Sildenafil 70 MG Tablet
Provider-reviewed cash-pay program.
What Is Tadalafil/Sildenafil Combo?
The tadalafil/sildenafil combination is a compounded oral preparation that combines two PDE5 inhibitors in a single as-needed tablet. Tadalafil has a half-life of roughly 17.5 hours, providing an extended window of effect; sildenafil has a half-life of about 4 hours, contributing rapid onset. Compounding them aims to provide both characteristics in a single dose form.
What It May Help With
This combination is used for adult men with erectile dysfunction who want the duration of tadalafil paired with the rapid onset of sildenafil. Like any PDE5 therapy, it requires provider evaluation to confirm appropriateness and screen for interactions.
Who May Be a Candidate
Most adult men with ED who do not have contraindications to PDE5 inhibitors are potential candidates. Men taking nitrates (for chest pain), certain alpha blockers, or with significant cardiovascular disease should not take PDE5 inhibitors without specialist input. Your OakMD provider will review your full health profile before prescribing.
How OakMD Works
OakMD is a telemedicine platform connecting eligible adults with licensed providers. If you're interested in Tadalafil/Sildenafil Combo, the process begins with a brief online intake form. A licensed provider will review your health history, symptoms, and goals — and determine if treatment is appropriate for you.
If you are a candidate, your provider will create a personalized treatment plan and guide you through next steps. There are no in-person visits required.
Common Questions
How is this combination dosed?
The combination is taken as needed before sexual activity. Your provider will confirm the appropriate timing and any plan-specific instructions. Do not take it alongside another PDE5 inhibitor.
What are the most common side effects?
Headache, flushing, nasal congestion, and indigestion are the most commonly reported effects with PDE5 inhibitors. Tadalafil is more commonly associated with back or muscle aches. Severe side effects are rare but should be discussed with your provider.
Ready to Get Started?
Complete a brief online intake. A licensed provider will review your information and determine if treatment is appropriate for you.
The information provided through the OakMD® website, assessments, product pages, checkout flows, communications, and related services is for general informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
Medical Disclaimer: The information provided through the OakMD® website, assessments, product pages, checkout flows, communications, and related services is for general informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
Prescription treatment, if any, is provided only after review by a US-licensed provider and only if clinically appropriate. Read the full Medical Disclaimer.
Three Steps to Start
Continue with the provider network
Choose your plan and continue through the secure link supplied for that program.
Provider review
A licensed provider reviews your information and determines whether treatment is appropriate.
Receive your medication
Your medication is shipped discreetly to your door from a licensed pharmacy, with ongoing care messaging available.
About This Program
How does the combination work?
Both medications inhibit PDE5 and increase blood flow to the penis through cGMP. Tadalafil contributes extended duration (up to 36 hours); sildenafil contributes faster onset. Together in one tablet, the formulation is taken as needed before activity.
Is this a compounded medication?
Yes. The combo is dispensed by a licensed compounding pharmacy under provider supervision.
How is it dosed?
The combination is taken as needed before sexual activity. Your provider will confirm the appropriate timing and any instructions specific to your plan. Do not take it with another PDE5 inhibitor.
Compounded medications are not approved by the U.S. Food and Drug Administration (“FDA”), and the FDA does not review compounded medications for safety, effectiveness, or quality before they are marketed.
Prescription treatments are subject to provider review. Not all individuals are candidates for treatment. The prices, consultation fees, medication charges, shipping charges, taxes, recurring charges, and any other material fees applicable to your purchase will be disclosed before you authorize payment.
Completing an assessment, checkout, payment authorization, or account creation does not guarantee that treatment will be prescribed. If a plan includes recurring billing, recurring clinical review, refills, or subscription services, the billing cadence, renewal terms, cancellation process, refill conditions, and applicable fees will be disclosed at checkout or in your account.